The client asks the nurse which antihistamines are available as intranasal sprays. Which response by the nurse is most appropriate?(Select all that apply.)

1. Loratadine (Claritin)
2. Diphenhydramine (Benadryl)
3. Olopatadine (Patanase)
4. Azelastine (Astelin)
5. Neo-synephrine (Afrin)


3, 4

Rationale 1: Loratadine (Claritin) is not available as a nasal spray.
Rationale 2: Diphenhydramine (Benadryl) is not available as a nasal spray.
Rationale 3: Azelastine (Astelin) is approved for nonallergic rhinitis. Although it is a first-generation agent, azelastine causes less drowsiness than do others in its class because it is applied locally to the nasal mucosa, and limited systemic absorption occurs. Olopatadine (Patanase) is a second-generation antihistamine approved in 2008 for allergic rhinitis.
Rationale 4: Azelastine (Astelin) is approved for nonallergic rhinitis. Although it is a first-generation agent, azelastine causes less drowsiness than do others in its class because it is applied locally to the nasal mucosa, and limited systemic absorption occurs. Olopatadine (Patanase) is a second-generation antihistamine approved in 2008 for allergic rhinitis.
Rationale 5: Neo-synephrine (Afrin) is a decongestant.

Global Rationale: Azelastine (Astelin) is approved for nonallergic rhinitis. Although it is a first-generation agent, azelastine causes less drowsiness than do others in its class because it is applied locally to the nasal mucosa, and limited systemic absorption occurs. Olopatadine (Patanase) is a second-generation antihistamine approved in 2008 for allergic rhinitis.

Nursing

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