A nurse is planning to administer acetaminophen (Tylenol) per rectum to a client. The nurse expects:
1. Onset of action to be slower than that of the oral route.
2. Onset of action to be faster than that of the oral route.
3. Onset of action to be faster than that of the intravenous route.
4. The onset of constipation.
Correct Answer: 1
Rationale 1: The onset of action for drugs given per rectum is usually slower than that of the oral route.
Rationale 2: The onset of action for drugs given per rectum is not faster than that of the oral route.
Rationale 3: The intravenous route of drug administration has been shown to have the fastest onset of action of all the routes of drug administration.
Rationale 4: Constipation is not usually an adverse effect of rectal acetaminophen administration.
Global Rationale: The onset of action is usually slower than the oral route, and drug action is limited by the length of time that the patient can retain the drug without defecation. Onset of action is slower than intravenous route. Constipation is not an adverse effect of rectal acetaminophen administration.
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