Isoproterenol is an effective bronchodilator. It also produces adverse cardiovascular effects because of its effect on which receptors?
1. Alpha-2 receptors
2. Beta-1 receptors
3. Alpha-1 receptors
4. Dopamine receptors
Correct Answer: 2
Rationale 1: Isoproterenol is not an alpha-2 receptor agonist. Alpha-2 receptor agonists are used for treatment of hypertension. They act through nonautonomic central mechanisms.
Rationale 2: Isoproterenol activates beta-1 receptors to increase the strength of myocardial contraction and improve cardiac output. This increases its potential for causing serious side effects.
Rationale 3: Isoproterenol has no effect on alpha-1 receptors. Alpha-1 receptor agonists are used for pharmacotherapy of nasal congestion and hypotension.
Rationale 4: Isoproterenol has no effect on dopaminergic receptors.
Global Rationale: Isoproterenol activates beta-1 receptors to increase the strength of myocardial contraction and improve cardiac output. This increases its potential for causing serious side effects. Isoproterenol is not an alpha-2 receptor agonist. Alpha-2 receptor agonists are used for treatment of hypertension. They act through nonautonomic central mechanisms. Isoproterenol has no effect on alpha-1 receptors. Alpha-1 receptor agonists are used for pharmacotherapy of nasal congestion and hypotension. Isoproterenol has no effect on dopaminergic receptors.
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