When performing antiviral susceptibility testing, a standard inoculum must be used. If the inoculum quantity is too large, then the isolate will appear:
a. susceptible.
b. intermediate.
c. resistant.
d. indeterminate.
C
The final result of antiviral susceptibility testing is determined by many variables; these variables also act to hinder the standardization of antiviral susceptibility testing. Some of these variables include: (1) cell line used to grow the virus, (2) viral inoculum titer, (3) incubation time of the culture, (4) concentration range of the antiviral tested, (5) reference strains, (6) assay method, (7) endpoint criteria, (8) calculation of the endpoint, and (9) interpretation of the endpoint. Each of these factors has variables that affect the final results. For example, if the inoculum quantity is too large, then a susceptible isolate may appear resistant; if the inoculum quantity is too small, then the isolate may appear susceptible. Because of each of these variables, establishing control strains to also be tested when performing antiviral susceptibility testing is imperative.
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