Upon getting his annual physical exam, a 55-year-old man is noted to have a body mass index of 33 (above 30 = obese) and high blood pressure
His blood chemistry indicates hyperlipidemia, hypertriglyceridemia, and hypercholesterolemia. Furthermore, his fasting blood glucose level is 120 mg/dL (elevated). His physician suspects type 2 diabetes and orders a glucose tolerance test. The patient drinks 75 g of glucose and then has his blood glucose measured at 2 hr. The 2-hr glucose level is 190 mg/dL (high end of glucose intolerance range; the diagnosis of diabetes is equal to or greater than 200 mg/dL).
The most likely reason for this patient's glucose intolerance is:
A. autoimmune destruction of the ? cells
B. impairment of ATP-sensitive K+ channel
C. insulin resistance
D. low leptin levels
E. impairment of GLUT2 function
ANS: C
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