A client has been admitted to the intensive care unit of the hospital after developing toxic epidermal necrolysis (TEN) consequent to the administration of a sulfonamide antibiotic

What pathophysiologic phenomenon is likely the greatest immediate threat to this client's health?
A) The development of bacterial cellulitis on compromised skin surfaces
B) Fluid and electrolyte imbalances resulting from the loss skin integrity
C) A cascading autoimmune response that may result in shock
D) The presence of diffuse lesions and skin sloughing on the client's mucous membranes


Ans: D
Feedback:
TEN is manifested by large areas of denuded skin resulting from separation at the basement membrane. This sloughing and necrosis can be fatal if it occurs in the airway and on the other mucous membranes. Infection and fluid and electrolyte imbalances may occur, but the most immediate threat results from the immediate consequences of skin sloughing. A cascading autoimmune response does not occur in TEN.

Health & Biomechanics

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