What conclusion has been drawn regarding the use HFOV in terms of limiting the development of VILI?
A. HFOV is useful in limiting VILI in patients with ALI.
B. HFOV is useful in limiting VILI in patients with ALI when low FIO2s are used.
C. HFOV is useful in limiting VILI in patients with ALI when high FIO2s are used.
D. The data did not detect any difference between HFOV and conventional, low-VT ventilation in limiting VILI in patients with ALI.
?ANS: D
A. Incorrect response: See explanation D.
B. Incorrect response: See explanation D.
C. Incorrect response: See explanation D.
D. Correct response: The trial conducted to determine if HFOV might be a modality to limit VILI in patients with ALI was underpowered. The comparison of HFOV and conventional, low-VT ventilation (6-10 ml/kg actual body weight; mean 8 ml/kg) proved inconclusive, and further randomized trials are needed.
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