If the process of positive selection did not occur, then
a. a condition resembling immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) would develop
b. a condition resembling autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED) would develop
c. naive T cells would be unable to undergo differentiation in secondary lymphoid tissues
d. malignant transformation would be more likely because of the accumulation of multiple mutations
e. only a very small percentage of circulating T lymphocytes would be able to become activated.
E
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