A physician has prescribed difenoxin with atropine to a client with acute diarrhea. The client informs the nurse that he is also taking MAOI antidepressants
The nurse would assess the client for which of the following that might result from the interaction of the two drugs?
A) Decreased effect of difenoxin
B) Increased risk of hypertensive crisis
C) Increased cholinergic blocking adverse reactions
D) Increased risk of CNS depression
Ans: B
Feedback:
The nurse should monitor the client for an increased risk of hypertensive crisis as an effect of the interaction between difenoxin with atropine and MAOI antidepressants. When the client is administered antihistamines, opioids, sedatives, or hypnotics with antidiarrheal drugs, there will be increased risk of CNS depression. When the client is administered antihistamines and general antidepressants with antidiarrheal drugs, there will be increased cholinergic blocking adverse reactions. There will not be a decreased effect of difenoxin when there is an interaction between difenoxin and MAOI antidepressants.
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