Compare results of various tests in effective versus ineffective erythropoiesis
a. Both have increased rate of erythropoiesis in the bone marrow.
b. Both have an elevated reticulocyte production index (RPI) greater than 3.
c. Both have normal release of RBCs from the bone marrow.
d. Both have significantly shortened red cell survival in circulation.
ANS: A
In both effective and ineffective erythropoiesis, the rate of red cell production in the bone marrow is increased (increased erythropoiesis). However, release to circulation differs in the two: it is successful in effective, but not in ineffective where significant intramedullary loss occurs. Thus the RPI is greater than 3 in effective, but usually less than 2 in ineffective. Red cell survival in circulation is significantly decreased in effective, but essentially normal or insignificantly shortened in ineffective.
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