Explain the processes that lead to the exocytosis of neurotransmitter from a presynaptic cell. Which components are recycled? Which ion is important in triggering exocytosis?
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Action potential arrives in synaptic terminal, and stimulates opening of voltage-regulated calcium channels. The resulting calcium influx triggers exocytosis of synaptic vesicle contents. The phospholipids of the vesicle
membranes are recycled, either from fusion of vesicles then later formation of new vesicles from the same molecules; or from the kiss-and-run model, in which the vesicle phospholipids are not incorporated into the membrane at all, but remain as vesicles that can be refilled with neurotransmitter.
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