Your friend has just joined a lab that studies vesicle budding from the Golgi and has been given a cell line that does not form mature vesicles
He wants to start designing some experiments but wasn't listening carefully when he was told about the molecular defect of this cell line. He's too embarrassed to ask and comes to you for help. He does recall that this cell line forms coated pits but vesicle budding and the removal of coat proteins don't happen. Which of the following proteins might be lacking in this cell line?
(a) clathrin
(b) Rab
(c) dynamin
(d) adaptin
(c) Given that coated pits can form but no vesicle budding is seen, dynamin is the most likely answer. Since coated pits are formed, clathrin and adaptin are unlikely to be the answer, because they are involved in the initial shaping of the vesicle into the pit [choices (a) and (d)]. Rab proteins are involved in the recognition of the transport vesicle with its target membrane and not with vesicle budding [choice (b)].
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