Constipation is a side effect of opioid use caused by the:
A. spasmolytic activity on smooth muscle and mu2 receptors in the GI tract.
B. spasmogenic activity of opioids on smooth muscle and mu2 receptors in the gastrointestinal (GI) tract.
C. spasmogenic activity on smooth muscle and mu1 receptors in the GI tract.
D. spasmolytic activity on smooth muscle and mu1 receptors in the GI tract.
Answer: B
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