All of the following are key mediators of immediate hypersensitivity reactions EXCEPT:
A. Mast cells
B. Basophils
C. IgE
D. Macrophages
E. TH2 cells
ANS: D. The main cellular mediators of immediate hypersensitivity reactions are mast cells, basophils, and eosinophils. IgE antibody plays a major role in sensitizing these cellular mediators for subsequent activation. Activation of TH2 cells is required for appropriate release of cytokines, such as interleukin (IL)-4 and IL-13, which stimulate IgE class switching in B cells. In contrast, macrophages are effector cells in delayed-type hypersensitivity reactions.
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