The patient is receiving a statin drug. Which assessment data would be a priority for the nurse to report to the physician?
1. Bowel sounds markedly increased in all four quadrants of the abdomen
2. Urine output of 200 mL/hour
3. Urine output of 20 mL/hour
4. Moderate elevation in liver function tests (LFTs)
3
Rationale 1: Increased bowel sounds will be heard with diarrhea, but diarrhea is a common side effect of statin therapy and is not considered a serious side effect initially.
Rationale 2: A urine output of 200 mL/hour does not indicate renal failure, which occurs with rhabdomyolysis.
Rationale 3: Rhabdomyolysis is a rare, but serious, side effect of statin drugs. Contents of muscle cells spill into the systemic circulation causing potentially fatal, acute renal failure. Urine output of less than 30 mL/hour is considered renal failure.
Rationale 4: Elevation of liver function tests (LFTs) may occur during statin therapy, but this is not as high a priority as acute renal failure.
Global Rationale: Rhabdomyolysis is a rare, but serious, side effect of statin drugs. Contents of muscle cells spill into the systemic circulation causing potentially fatal, acute renal failure. Urine output of less than 30 mL/hour is considered renal failure. A urine output of 200 mL/hour does not indicate renal failure, which occurs with rhabdomyolysis. Elevation of liver function tests (LFTs) may occur during statin therapy, but this is not as high a priority as acute renal failure. Increased bowel sounds will be heard with diarrhea, but diarrhea is a common side effect of statin therapy and is not considered a serious side effect initially.
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