You are studying a disease that is known to be caused by a single nucleotide change in a single gene, although the effect this change ultimately has on the protein's structure and function is unknown. You have DNA samples from multiple patients that you suspect of having this disease. What is the most efficient way to test the samples for the relevant mutation?
A) Preimplantation genetic diagnosis
B) PCR amplification followed by Sanger DNA sequencing
C) PCR amplification followed by gel electrophoresis
D) High-throughput exome sequencing
E) High-throughput genome sequencing
B) PCR amplification followed by Sanger DNA sequencing
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People tend to crave sweet and salty foods, but dislike bitter foods. What is the evolutionary
explanation for this? What will be an ideal response?
Which platelet hormone aids in the prevention of blood loss?
a. ATP b. serotonin c. heparin d. fibrinogen e. thrombin
The first mammals very likely arose from
A. dinosaurs. B. therapsids. C. amphibians. D. thecodonts.
Which of the following statements correctly describes why a series of closely spaced action potentials causes a sustained contraction rather than a series of closely spaced twitches?
A. Release of Ca2+ from the sarcoplasmic reticulum through channels is slow compared to the uptake of Ca2+ into the SR via ATP-dependent pumps, resulting in Ca2+ slowly trickling into the sarcomeres between closely spaced action potentials. B. Ca2+ ions are released quickly from troponin, keeping the Ca2+ concentration in the cytosol high between closely spaced action potentials. C. When a series of action potentials is closely spaced, there is not sufficient time for Ca2+ uptake into the sarcoplasmic reticulum between action potentials, and Ca2+ remains bound to troponin throughout the series. D. Fewer Ca2+ ions are released from the sarcoplasmic reticulum as a result of several closely spaced action potentials than as a result of a single action potential.