Which statement is accurate regarding pharmacotherapy in the older adult?
1. Increased body water can lead to a higher risk of drug toxicity.
2. Plasma levels are increased, leading to a heightened drug response.
3. Generally, drug doses should be increased due to prolonged drug metabolism.
4. Drug absorption is slower due to increased gastric pH.
Correct Answer: 4
Rationale: The elderly have an increase in gastric pH, which slows absorption. Plasma levels are lower, causing a diminished drug response. Body water is reduced, leading to a higher risk of drug toxicity. Generally, drug doses are reduced because of prolonged drug metabolism.
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