An Asian patient comes to the clinic. Upon assessment, the nurse notes a slight yellow tint to the skin and sclera, edema, and hepatomegaly
The drug history reveals that the patient has been taking rosuvastatin (Crestor) for 6 months. The nurse is concerned, because rosuvastatin (Crestor) has been shown to
a. cause renal and pancreatic toxicity specifically in Asian patients.
b. cause hepatotoxicity that immediately leads to renal failure.
c. create myoglobin in the urine, leading to hepatotoxicity.
d. reach levels twice as high in Asians as in Caucasians, resulting in a greater chance of hepatotoxicity.
ANS: D
Rosuvastatin reaches abnormally high levels in people of Asian heritage. Consequently, hepatotoxicity may occur more often in Asians patients because of the high level of the drug in the blood.
Rosuvastatin does not cause renal and pancreatic toxicity.
Hepatotoxicity does not necessarily lead to renal failure.
Rosuvastatin does not create myoglobin in the urine.
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