What role does stress play in atopic dermatitis?
What will be an ideal response?
In a normal immune system Th1 and Th2 immunity are in proper balance. However, in eczema, there is too much Th2 relative to Th1 . Upon reviewing the allergy literature, Hashizume and Takigawa concluded that acute stressors that chronically and repeatedly raise the anxiety levels of patients with atopic dermatitis lead to a worsening of allergic symptoms by dysregulating the immune system through enhancing Th2 responses. This model of stress-induced dysregulation toward Th2 immunity can be applied to all the atopic disorders. In a review by Marshall and Agarwal, the authors suggested "that chronic stress does not simply suppress the immune system, but induces a shift in the type-1/type-2 cytokine balance toward a predominant type-2 cytokine response. Such a change would favor the inflammatory milieu characteristic of asthma and allergic diseases."
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