Receptor-mediated endocytosis brings in specific material by engulfing it in vesicles. What factors, either directly or indirectly, are related to this process? Choose all that apply.A) It is a passive process.B) It helps to increase membrane fluidity by helping to transport cholesterol into the cell.C) It is an active process.D) It uses carrier proteins.E) A clathrin coat is present.

Question

What will be an ideal response?

Answer 1

B, C, E

Clarify Question
• What is the key concept addressed by the question?
        o The question asks about receptor-mediated endocytosis.
• What type of thinking is required?
        o You are being asked to apply your knowledge about receptor-mediated endocytosis. 

Gather Content
• What do you know about receptor-mediated endocytosis? What other information is related to the question?
        o Molecules are often transported into eukaryotic cells through receptor-mediated endocytosis. These molecules first bind to specific receptors in the plasma membrane-they have a conformation that fits snugly into the receptor. The portion of the receptor molecule that lies inside the membrane is trapped in an indented pit coated on the cytoplasmic side with the protein clathrin. Each pit acts like a molecular mousetrap, closing over to form an internal vesicle when the right molecule enters the pit. Large molecules like low density lipoprotein that carry cholesterol through the blood are taken up by this process. 

Choose Answer
• Given what you now know, what information and/or problem solving approach is most likely to produce the correct answer?
        o Receptor-mediated endocytosis is an active process in which clatherin coated pits bring in molecules bound to receptors on the surface of the cell. Cholesterol is taken into cells by this process. It is not passive diffusion of molecules through carrier proteins in the membrane. 

Reflect on Process
• Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
        o This question asked you to apply your knowledge about receptor-mediated endocytosis. If you got the correct answer, great job! If you got an incorrect answer, where did the process break down? Did you recall that clathrin coated pits were involved? Did you think the process involved passive diffusion through a carrier protein?