Select the statement that is consistent with the mechanism of action of phenytoin (Dilantin) that helps decrease the occurrence of a seizure.
A. Phenytoin decreases the inhibitory effects of the inhibitory neurotransmitter gammaaminobutyric acid (GABA), which suppresses the excitability of epileptogenic neurons.
B. Phenytoin decreases the inactivation of Na+ ion channels to decrease high-frequency firing of neurons and inhibition of Ca ++ ion channels.
C. Phenytoin prolongs the inactivation period of sodium (Na+) channels in the nerve membrane, leading to a reduction in the generation of high-frequency repetitive firing of action potentials from neurons involved in initiating seizures.
D. None of the above are correct.
Answer: C
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