When administering a drug-protein–bound drug to a client, what can the nurse expect?
1. Duration of action will be prolonged.
2. Drug excretion will be accelerated.
3. Metabolism of the drug will be delayed.
4. Onset of drug action will be prolonged.
Correct Answer: 1
Rationale 1: The portion of the drug that is protein bound is not available to the tissues, but as it is released, it becomes a free drug; a drug that is highly protein-bound has a high percentage of bound or unavailable drug that will produce a longer duration of action.
Rationale 2: Drug excretion will not be accelerated.
Rationale 3: Metabolism of the drug will occur as the free drug portion becomes available.
Rationale 4: Onset of action of the drug will not be affected.
Global Rationale: The portion of the drug that is protein bound is not available to the tissues, but as it is released, it becomes a free drug; a drug that is highly protein bound has a high percentage of bound or unavailable drug that will produce a longer duration of action. Drug excretion will not be accelerated. Metabolism of the drug will occur as the free drug portion becomes available. Onset of action of the drug will not be affected.
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