What would be the response if a person's nephrons were not able to filter normally due to scarring of the proximal convoluted tubule leading to inhibition of reabsorption?
A. Increased urine output, fluid volume deficit
B. Decreased urine output, fluid volume deficit
C. Increased urine output, fluid volume overload
D. Decreased urine output, fluid volume overload
A
The nephrons filter about 120 mL/min. Most of this filtrate is reabsorbed in the proximal convo-luted tubule. If the tubule were not able to reabsorb the fluid that has been filtered, urine output would greatly increase, leading to rapid and severe dehydration.
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