The nurse is reviewing medication information with a nursing student prior to administering an oral drug and notes that the drug has extensive first-pass effects
Which statement by the student indicates a need for further teaching about this medication?
a. "The first-pass effect means the drug may be absorbed into systemic circulation from the intestinal lumen."
b. "The first-pass effect means the drug may be changed to an inactive form and excreted."
c. "The first-pass effect means the drug may be changed to a metabolite, which may be more active than the original."
d. "The first-pass effect means the drug may be unchanged as it passes through the liver."
ANS: A
Drugs that undergo first-pass metabolism are absorbed into the portal vein from the intestinal lumen and go through the liver where they are either unchanged or are metabolized to an inactive or a more active form.
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