Which of the following is normal in hereditary spherocytosis?
a. Red cell morphology
b. Direct antiglobulin test
c. Osmotic fragility
d. Reticulocyte count
ANS: B
The direct antiglobulin test detects antibodies present on the red blood cell (RBC) membrane. Because they are not present in hereditary spherocytosis, this test will be negative (normal). Red cell morphology ideally shows spherocytes (depending on the number present), the osmotic fragility is increased, and the reticulocyte count is increased.
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