Explain the function of cAMP in catabolite repression
What will be an ideal response?
Answer: Adenylate cyclase synthesizes the regulatory nucleotide cAMP, and when the substrate glucose is present this process is inhibited (or repressed). This means glucose is a preferred substrate for catabolism in cells that contain this mechanism, such as E. coli. Once glucose has been used up, cAMP is then produced, which forms a cAMP-CAP-DNA complex, resulting in transcription of the genes that the CAP correspond to, and catabolism of an additional substrate can be performed.
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