Large pre-B cells undergo clonal expansion before the rearrangement of light-chain loci. Which of the following are beneficial consequences of clonal expansion? (Select all that apply.)

a. Autoreactive B cells are eliminated before the expenditure of energy needed to rearrange a functional light-chain gene.
b. The energy used to make a functional heavy chain is not wasted as a result of the inability to produce a functional light chain.
c. RAG gene expression is decreased, which in turn signals light-chain rearrangement.
d. A diverse population of immature B cells is generated that express the same ? chain but a distinct light chain.
e. Approximately 85% of small pre-B cells will progress to the immature B-cell stage.


b, d, e

Health & Biomechanics

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