A client's husband is a chemist. He asks the nurse the action by which SSRIs lift depression. The
nurse should explain that SSRIs
a. make more serotonin available at the synaptic gap.
b. destroy increased amounts of neurotransmitter.
c. increase production of acetylcholine and dopamine.
d. block muscarinic and a1 norepinephrine receptors.
ANS: A
Depression is thought to be related to lowered availability of the neurotransmitter serotonin. SSRIs
act by blocking reuptake of serotonin, leave a higher concentration available at the synaptic cleft.
Option B: SSRIs actually prevent destruction of serotonin. Option C: SSRIs have no effect on
acetylcholine and dopamine production. Option D: SSRIs do not produce muscarinic or a1
norepinephrine blockade.
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