Antipsychotic drugs are sometimes administered by depot injection because
a. these substances produce euphoria when taken orally in high doses and are liable to be abused.
b. their bioavailability is extremely low when taken orally, due to the effects of first-pass metabolism.
c. their extremely short half-lives necessitate an unrealistically frequent dosing schedule.
d. quick absorption into the bloodstream, as is the case with intravenous injection, can lead to deleterious effects on the body, including seizures and organ failure.
e. the effects of these substances are not pleasant and compliance tends to be low.
Answer: E
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