Which statement about an inherited mutation in a cancer gene allele is accurate?
A. A person inheriting such a mutation has a 100% risk for developing a specific cancer type.
B. The cancer risk increases but additional mutations are required for cancer devel-opment.
C. The mutated gene allele will be take over the normal allele in most tissues.
D. The cancer risk is increased only in sex hormone–sensitive tissues.
B
For cancer to develop in a tissue, both suppressor gene alleles must be mutated and nonfunctional or both oncogene alleles must be mutated and functional. If one gene allele is inherited as mu-tated, another mutation must still occur for cancer to develop.
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