The p300/CBP (CREB-binding protein) proteins are histone acetyltransferases that help regulate the transcription of many genes. Based on this information you can conclude that these proteins
A. acetylate purines.
B. remodel chromatin.
C. recruit helicases.
D. physically connect activator proteins.
Clarify Question
· What is the key concept addressed by the question?
· What type of thinking is required?
· What key words does the question contain and what do they mean?
Gather Content
· What do you already know about histone acetyltransferases?
Consider Possibilities
· Consider the different answer options. Which can you rule out?
Choose Answer
· Given what you now know, what information and/or problem solving approach is most likely to produce the correct answer?
Reflect on Process
· Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
B. remodel chromatin.
Clarify Question
· What is the key concept addressed by the question?
o This question addresses histone acetyltransferases.
· What type of thinking is required?
o This question is asking you to analyze the information given, using logic, to dissect the problem and determine the answer.
· What key words does the question contain and what do they mean?
o Histone acetyltransferases are enzymes that acetylate (that is, add a -COCH3 group) to histone proteins.
Gather Content
· What do you already know about histone acetyltransferases?
o Histone acetyltransferases are a class of proteins that modify histones.
o Histones are proteins that form much of the structure of chromatin – that is, the DNA and proteins of the chromosome.
Consider Possibilities
· Consider the different answer options. Which can you rule out?
o Would histone acetyltransferases act to acetylate purines? No, they acetylate histone proteins, not the DNA itself.
o Would histone acetyltransferases act to recruit helicases? No, they change the structure of chromatin by modifying histones.
o Would histone acetyltransferases act to physically connect activator proteins? No. Although sometimes called coactivators, they activate by modifying chromatin structure, not directly connecting transcription factors.
Choose Answer
· Given what you now know, what information and/or problem solving approach is most likely to produce the correct answer?
o Would histone acetyltransferases act to remodel chromatin? Yes! That is their mode of action.
Reflect on Process
· Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
o This question asked about the role of p300/CBP proteins.
o The question required you to analyze the information given, using logic, to dissect the problem and determine the answer.
o Did you recognize that histone acetyltransferases modify chromatin structure?
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A. mild susceptibility to infection due to T cell defects B. increased antibody diversity from B cells C. severe combined immunodeficiency (SCID) of both B and T cells D. increased resistance to infection due to enhanced B and T cell function Clarify Question What is the key concept addressed by the question? What type of thinking is required? Gather Content What do you already know about the VDJ segments? What other information is related to the question? Choose Answer Given what you now know, what information is most likely to produce the correct answer? Reflect on Process Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
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A) older birds prefer lower elevations. B) competitive abilities change along environmental gradients. C) of population cycling. D) there are more predators at higher elevation.