Which of the following is true of red cell precursors as they mature?
a. The nuclear-to-cytoplasmic ratio increases.
b. The cells become larger.
c. The cytoplasm becomes less basophilic.
d. The nucleoli become more prominent.
ANS: C
In general, basophilia decrease as the red cell matures (one exception to this: the basophilic normoblast is characteristically more basophilic than its precursor, the pronormoblast). The nuclear-to-cytoplasmic ratio actually decreases, the cells become smaller, and nucleoli become less prominent and eventually disappear.
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