The nurse educator is explaining the factors that impact the transfer of medications across the placenta. Which factor would be responsible for higher concentrations of a drug being transferred to the fetus through the placenta?
1. Low degree of metabolic activity of the placenta
2. Increased blood flow to the placenta
3. Plasma drug level in the mother
4. Increased blood volume of the mother
Correct Answer: 3
Rationale 1: The placenta has a high metabolic activity level.
Rationale 2: Decreased blood flow to the placenta results in trapped circulating drugs; therefore, higher levels of drug concentration would be present in the fetus.
Rationale 3: Higher concentrations of drugs in the maternal blood lead to higher levels of circulating drug to the placenta.
Rationale 4: Increased blood volume of the mother does not affect amount of drug that is transferred to the fetus.
Global Rationale: Higher concentrations of drugs in the maternal blood lead to higher levels of circulating drug to the placenta. The placenta has a high metabolic activity level. Decreased blood flow to the placenta results in trapped circulating drugs; therefore, higher levels of drug concentration would be present in the fetus. Increased blood volume of the mother does not affect amount of drug that is transferred to the fetus.
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