Niacin and aspirin have been prescribed for a client diagnosed with hyperlipidemia. Which statement regarding why this drug combination is prescribed is the most accurate?
1. "A common side effect of niacin therapy is joint pain."
2. "Taking niacin and aspirin together increases the therapeutic effect of niacin."
3. "Aspirin can decrease discomfort associated with niacin therapy."
4. "Severe headaches are common during the early weeks of niacin therapy."
Correct Answer: 3
Rationale 1: Joint pain is not associated with nicotinic acid therapy.
Rationale 2: There is no pharmacodynamic interaction between nicotinic acid and aspirin.
Rationale 3: One aspirin tablet administered 30 minutes before a dose of niacin might minimize the frequent side effect of flushing associated with niacin.
Rationale 4: Flushing associated with nicotinic acid involves peripheral vasculature, not vasculature in the brain.
Global Rationale: One aspirin tablet administered 30 minutes before a dose of niacin might minimize the frequent side effect of flushing associated with niacin. Joint pain is not associated with nicotinic acid therapy. There is no pharmacodynamic interaction between nicotinic acid and aspirin. Flushing associated with nicotinic acid involves peripheral vasculature, not vasculature in the brain.
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