What is the earliest morphologically identifiable cell in the granulocyte maturation sequence?
a. Pluripotent stem cell
b. Colony-forming unit–granulocyte, erythrocyte, monocyte, and megakaryocyte (CFU-GEMM)
c. Myeloblast
d. Myelocyte
ANS: C
The earliest cell that can be identified by morphology, using Wright stain, as belonging to the granulocyte maturation sequence is the myeloblast. The pluripotent stem cell and the CFU-GEMM are identified by various receptors present on the cell membrane using monoclonal antibodies and flow cytometric techniques. The myelocyte is a later stage of development than the myeloblast.
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