In a disease associated with a nucleotide repeat, anticipation is often noticed in subsequent generations, usually associated with a more severe phenotype. Which of the following is a more likely cause of anticipation?

Question

A) The CAG alleles with a high number of repeats are unstable and change size from generation
to generation.
B) Subtle phenotypic nuances are more often sought by a physician.
C) Family members are exposed to the same mutagens.
D) Highly repeated sequences are expressed more often.
E) The sequences have greater stability in later generations.

Answer 1

A