Which sentence best explains why, during DNA replication, DNA ligase is most active on the lagging strand?
a. The lagging strand requires DNA ligase to couple the RNA primer to the Okazaki fragments.
b. The lagging strand synthesizes DNA in the 3' ? 5' direction.
c. The lagging strand is synthesized more slowly, and DNA ligase speeds up the DNA polymerase.
d. The lagging strand contains more short DNA segments than the leading strand, and these short segments are joined together by DNA ligase.
Answer: d. The lagging strand contains more short DNA segments than the leading strand, and these short segments are joined together by DNA ligase.
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