Compare and contrast the affinity hypothesis and altered peptide hypothesis to explain the thymic selection paradox (why we don't negatively select all cells that we positively select)
What will be an ideal response
The affinity hypothesis states that the strength of the TCR/MHC/peptide interaction determines whether a T cell is positively or negatively selected. The altered peptide hypothesis states that thymic epithelial cells express a special set of peptides that mediate positive selection. There is support for both hypotheses and both may contribute to the paradox of thymic selection.
You might also like to view...
Which type of memory can be accessed for conscious recollection? Choose the correct option
A) Nondeclarative memory C) Declarative memory B) Procedural memory D) Classical conditioning
Studying how climate affects physical activity habits is an example of an integration activity for directions in social studies
Indicate whether the statement is true or false
With nondisplaced fractures of the fingers, there is usually a great deal of:
A) swelling. B) deformity. C) pain. D) numbness.
The "good" cholesterol is a ________-density lipoprotein, which circulates in the blood and carries excess cholesterol back to the liver for elimination.
Fill in the blank(s) with the appropriate word(s).