Megaloblastic anemias caused by folic acid or vitamin B12 deficiencies can seriously affect RBC production. Which of the following lab results would correlate with this diagnosis?
A) Iron level of 70 ?g/dL (normal)
B) Mean corpuscular hemoglobin (MCV) 120 fL (high)
C) Platelet count 200,000 (normal)
D) Reticulocyte count 3.6% (high)
Ans: B
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Megaloblastic anemias are caused by impaired DNA synthesis that results in enlarged red cells (MCV >100 fL) due to impaired maturation and division. Folic acid and/or vitamin B12 do not have a critical role in normal iron and platelet levels or a high reticulocyte count.
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