Which of the following would create the lowest P50?
a. pH = 7.26 c. PCO2 = 32 mm Hg
b. pH = 7.35 d. Temperature = 39??C
ANS: C
A pH of 7.26 and 7.35 are acidotic and will cause a right shift in the oxyhemoglobin dissociation curve, increasing the P50 above 27 mm Hg (normal). A PCO2 of 32 mm Hg indicates alkalosis and will shift the oxyhemoglobin dissociation curve to the left, lowering the P50 below 27 mm Hg. A temperature of 39° C is hyperthermia and will cause a right shift in the curve, increasing the P50 above 27 mm Hg.
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