What feature of these mouse antibodies compromises their effectiveness in vivo and limits their use?
What will be an ideal response?
Mouse MoAbs are antigenic in species other than mice and stimulate anti-MoAb responses. Repeated doses will exacerbate this situation and lead to the formation and clearance of MoAb:anti-MoAb immune complexes before the antibody can bind to the T cells, thus rendering the mouse antibody ineffective. A type III hypersensitivity reaction resembling serum sickness can also result when small immune complexes are formed; that is, when MoAb levels exceed anti-MoAb levels. Hence, repeated doses are discouraged, and physicians must restrict this form of immunosuppressive therapy to one episode of rejection.
You might also like to view...
A particularly important step in diabetes treatment is to
A) decrease dietary fiber. B) eat more meat for protein. C) lose weight. D) enter a treatment facility.
Use the definitions given to complete the crossword puzzles.
 ACROSS 2 Night-blindness 3 Also called lazy eye 6 Also called hordeolum 8 Condition caused by weakness of external eye muscle 11 Mucous membrane protecting anterior eyeball 12 Outer layer of eyeball 13 Condition caused by irregular curvature of cornea DOWN 1 Bright green dye 4 Visual __________ measures sharpness of vision 5 Farsightedness 7 Condition caused by increased intraocular pressure 9 Nearsightedness 10 A(n) _________ chart is used to test visual acuity
Answer the following statements true (T) or false (F)
1. Otosclerosis affects the stapes bone. 2. An acoustic neuroma is a cancerous tumor of the sheath around the eighth cranial nerve. 3. Another term for labyrinthitis is inner ear infection. 4. A cochlear implant is a device to improve bone conduction hearing loss. 5. Audiometry is a test of hearing ability.
The "C" in RICE stands for "circulation."
Indicate whether the statement is true or false.