Manipulation of costimulatory signals has potential to treat tumors because
A. tumors that do not provide costimulation induce anergy instead.
B. it is relatively easy to isolate and introduce genes to tumor cells.
C. modified tumors with increased costimulatory activity can be reintroduced to patients.
D. blockage of CTLA-4 on tumors will increase T-cell activation.
E. All of the above.
E
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