Why is an Rh factor conflict usually a problem only for the second child and subsequent children born to the Rh negative mother? When it is a problem for the first child?

What will be an ideal response?


An Rh factor conflict is normally a problem only for the second child and subsequent Rh positive children born to an Rh negative mother. Rh negative people do not usually form antibodies to the Rh factor unless exposed to Rh positive blood. When an Rh negative mother carries an Rh positive child, the baby's blood could leak across the placenta and the mother would form Rh antibodies to the baby's blood. This could cause a problem for the baby in utero, even if it's the first child. As the mother's antibodies cross the placenta, the child's red blood cells would be destroyed by the antibodies, creating a condition known as HDN (Hemolytic Disease of the Newborn). It is more common for the second child, or subsequent children, of an Rh negative woman to encounter problems. During delivery, some bleeding is normal. An Rh negative woman will form antibodies to the Rh positive baby after being exposed to the baby's blood. In any subsequent pregnancies with Rh positive children, the mother's antibodies will cross the placenta and destroy the child's red blood cells.

Biology & Microbiology

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Fill in the blank(s) with correct word

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Why is the use of angiogenesis inhibitors less likely to have adverse side effects when used to treat cancers?

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