Briefly describe the process through which vitamin D deficiency impacts bone remodeling. Why is serum calcium level often normal in patients with vitamin D deficiency?
What will be an ideal response?
• Vitamin D plays a role in bone remodeling by increasing the absorption of key minerals in bone formation such as calcium and phosphorus and by promoting the reabsorption of these minerals in the kidneys. Additionally, vitamin D will stimulate osteoclast formation, which will cause bone resorption (release of calcium and phosphorus from the bone into the serum).
• Serum calcium levels are often normal in vitamin D deficient patients due to the body's tight regulatory control of serum calcium levels via the effects of parathyroid hormone, calcitonin, and vitamin D.
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