Why are Toll-like receptors (TLRs) important for adaptive immune responses?
What will be an ideal response?
Stimulation of TLRs on dendritic cells by pathogen components induces the expression of chemokine receptor CCR7 on the dendritic cell. This enables dendritic cells laden with pathogen antigens to migrate from the site of infection to the nearest draining lymph node in response to chemokines produced by the lymph node. Stimulation of TLRs and other receptors on dendritic cells and macrophages also induces the expression of B7 co-stimulatory molecules, which makes these cells into professional antigen-presenting cells that are able to activate naive T cells.
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A) Offering open-ended tasks B) Using self-competition C) Limiting the number of choices D) Bringing in a guest speaker who represents diversity in race and/or gender.
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