Gout typically affects which of the following joints primarily in the lower extremity?
1st metatarsophalangeal joint
ankle
1st tarsometatarsal joint
1st metacarpophalangeal joint
1st metatarsophalangeal joint
Rationale: Gout, typically hereditary, causes uric acid crystals to build up in joint spaces and an inflamed and painful joint. Gout commonly begins by affecting the first metatarsophalangeal joint.
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