Describe the roles of the following enzymes during DNA replication: ligase, single-stranded binding

protein (SSB), DNA polymerase III, primase, DNA helicase.



What will be an ideal response?


DNA helicase binds to an origin of replication and unwinds the two DNA strands which are then
bound by SSB to keep them apart. Primase uses the DNA as a template to make an RNA primer that
serves as a 3’ end for DNA polymerase III which extends the RNA primer with DNA nucleotides.
Once the RNA primers have been removed and replaced with DNA, any gaps in the sugar-phosphate
backbone are connected using ligase.

Biology & Microbiology

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