Describe factors that affect drug dissolution


The pH of the stomach and the gastric emptying rate are two of the most important nutrition-related factors impacting drug dissolution. Medications may require an acidic environment for dissolution. Achlorhydria, which is decreased production of hydrochloric acid, occurs in aging as well as some medical conditions such as HIV and AIDS. Medications that could affect gastric acidity include H2 blockers, proton-pump inhibitors, and antacids. Gastric emptying rate influences the amount of time in which dissolution can occur; medications that affect gastric emptying time include prokinetics, such as metoclopramide.

Nutritional Science

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