The nurse is explaining muscle function to a group of high school students during Health Class. In which order should the nurse discuss the neuromuscular junction? Place the steps 1 through 6 in order
A.___ Neuron releases acetylcholine.
B.___ Myosin shortens the sarcomeres and pulls the muscle fiber.
C.___ Calcium from the sarcoplasmic reticulum bonds to myosin heads.
D.___ Action potential travels down motor neuron to the synaptic end bulb.
E.___ Action potential travels into the transverse tubules to the sarcoplasmic reticulum.
F.___ Acetylcholine crosses into the synaptic cleft and bonds with receptors on motor end plate.
ANS:
A, D, F, E, C, B
The neuron releases the neurotransmitter, acetylcholine (Ach), which signals muscle contraction. An action potential travels along the motor neuron, reaching the synaptic end bulb. Acetylcholine is exocytosed into the synaptic cleft and bonds with receptors on the motor end plate. An action potential initiates and travels along the sarcolemma and into the transverse tubules, transferring to the sarcoplasmic reticulum. Calcium ions released from the sarcoplasmic reticulum bond to troponin of the thin filament, exposing bonding sites on actin for myosin heads. Myosin of the thick filament attaches and pulls the thin filament, shortening the sarcomeres and thus the muscle fiber.
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