The client is a 30-year-old man who has type 1 polycystic kidney disease (PKD-1). He asks whether his children could develop this disease. What is the nurse's best response?
A. "Because there is no identifiable pattern of inheritance with this disease, your children are not at an increased risk for developing polycystic kidney disease."
B. "Because the disease is sex-linked (x-linked) recessive, only your sons will be affected."
C. "Because this is a recessive disorder, your wife would also have to have the dis-ease for your children to have polycystic kidney disease."
D. "Because this is a dominant disorder, each of your children would have a 50% risk of having polycystic kidney disease."
D
Polycystic kidney disease type 1 (PKD-1) is transmitted as an autosomal dominant trait and, therefore, is not gender-specific. If one parent has PKD-1, each child has a 50% risk for the dis-order. If both parents have PKD-1, the risk is even greater.
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